Strategy and marketing in small markets?

On the internet there are many ideas for small businesses and for big businesses.
But few ideas deal specifically with marketing and strategy challenges in small markets such as Curacao and the Caribbean.
That, while we know that, because of consumer demands and expectations, the future lies in “niche markets” and even “localized” strategy (adapted to preferences of specific cities, neighborhoods, etc.). In our small markets we may easily literally end up with a “market of one”.
How can we overcome these challenges? How can we use and adapt existing tools for our small markets to make it worth our while?

These are the issues I wish to discuss in this blog. It is a thought that I am developing, hopefully assisted by your comments. So, not all posts deal with small markets.